John and Susan Houser

When my Dad found that he had prostate cancer he chose to go the medical route . After several months of treatments that almost killed him , The Dr told my Dad that he was now cancer free and could return to a normal life .

Three months later the cancer came back with a vengeance . He was informed that he could not go through chemo again , that the treatments would kill him .

I had been following his progress closely - from the beginning I had been suggesting natural remedies - Ellagic Acid . But my dad like so many had consigned his health over to the medical establisment .

When he was informed that they could no longer help him depression set in . His prostrate was so large he could not hardly urinate , and was in intense pain .

I asked my Dad if he would try a bottle of Ellagic Acid . He said he would so I mailed Ellagic Acid to him . In Just one week Dad's prostate shrunk down enough that he could urinate without pain , and in about a month his PSA was in normal ranges .

At The Raleigh Herb Shop , we teach prevention . Cleanse , Nourish ,Balance the body - and the body will heal itself as God intended .

Health and Wellnes Seminars held weekly .

We have several testimonies on file of people with all different types of cancer , who used Ellagic Acid , and received great benefits . Thanks for reading - John Houser The Raleigh Herb shop 919 875 1005

PLEASE READ THE FOLLOWING REPORT ------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------

THE "SCIENCE" OF ELLAGIC ACID CONSUMPTION IN CANCER PREVENTION

One of the pioneers in cancer prevention is Dr. Daniel Nixon (see The Cancer Recovery Eating Plan, Times Books, NY, 1994). Dr. Nixon's lab at the Hollings Cancer Center in the Medical University of South Carolina has examined the ability of ellagic acid to prevent colon and cervical cancers from developing. Preliminary evidence generated by his team of researchers has indicated that ellagic acid can slow the proliferation of both human colon and cervical cancer cells grown in experimental systems outside the body. These findings have led to the hypothesis that ellagic acid may be useful in humans susceptible to either of these two cancers. While not yet complete, clinical studies are in progress at the Medical University of South Carolina and studies in women susceptible to cervical cancer are just beginning. The colon trial will measure ellagic acid's ability to prevent the formation of colon polyps (which may be the precursor to colon cancer) and/or slow the growth of rapidly proliferating colon cells in human papilloma virus, which is responsible for this disease. These clinical evaluations will be conducted at the Medical University of SC and the University of Madrid Medical School in Madrid, Spain.

Some of the data published by Dr. Nixon and his team at the Medical University of South Carolina is presented here.

Following exposure to ellagic acid from red raspberries, human cervical cancer cells, infected with human papilloma virus (HPV), die within several days due to a process termed apoptosis. Ellagic acid causes the growth cycle arrest of cancer cells, thus, inhibiting cell division (mitosis) and cellular proliferation. Ellagic acid from red raspberries prevents destruction of a cellular regulatory gene, by HPV oncogenes (genes responsible for cancer induction) in cervical cells (is regarded as the safeguard of normal cellular division and inactivated, abnormal cell division/proliferation ensues). Similar protective effects were observed in breast, pancreas, esophageal, skin, colon, and prostate cancer cells exposed to ellagic acid. Consumption of 150 grams of red raspberries (the equivalent of 40 milligrams of ellagic acid) resulted in the appearance of circulating levels of ellagic acid in the serum one hour after ingestion. Four of HTN's Ellagic Acid 1-gram tablets equal approximately 40 milligrams or more of pure ellagic acid. In summary, the data from Dr. Nixon's lab and other investigators indicates that ellagic acid 1) activates detoxifying enzymes in the liver resulting in the clearing of cancer-causing chemicals (mutagens) in the serum, 2) prevents the binding of carcinogens to cellular DNA, 3) serves as an antioxidant in the scavenging and clearance of highly destructive oxygen free radicals, 4) induces apoptosis (programmed cell death) in cancerous cells, and 5) stimulates the immune system for the destruction of cancerous cells. Each of these attributes were found to be important in reducing the incidence of cancer in experimental models.

Finally, while the mechanism(s) are not yet known, research performed in Europe indicate that ellagic acid may also be useful in reducing the incidence of birth defects, promoting wound healing, and limiting chemically induced liver fibrosis. In addition, some investigators now believe that ellagic acid may be useful in the prevention of heart disease.

Could HTN's Ellagic Acid possibly be the answer 1 out of 2 people should be looking for? The effectiveness of ellagic acid is expected to be medically verified over the next several years with clinical and double blind studies for most types of cancer.

The Raspberry Revolution The miracle berry that helps fight cancer

In the year 1880, one in thirty people developed cancer in their lifetime.

Today, that figure is 1 in 2 - shocking statistics!

Cancer is surpassed only by heart disease as the number one killer in the United States. Modern medical intervention seems to be stuck as "cures" and "survival data" peak at approximately a 50% treatment success rate. Clinicians and researchers both agree however, that it is easier to prevent cancer than to cure it.

We are awash in a toxic wasteland. The air we breathe, the foods we eat, the water we drink, and even the water we cook and bathe in continuously expose us to the harmful effects of air pollution, pesticides, toxic run off, and the increased light due to the thinning of the ozone layer. Did you know:

Lawn Care: Ordinary house owners use 10 times as much pesticide per acre as farmers do. Most of it quickly runs into surface and ground water, poisoning our streams, lakes and wells. Automobiles: Cars put out less pollution today than ever before. But there are more cars than ever, all countries do not even have the strict emission standards as in the USA, and the millions of pounds of lead from years back are still in the dirt alongside the roads. Outgassing of volatile materials harmful to human health from asphalt, paint, insulation, new rugs, and furniture. All of the above pollutants and many more not mentioned create free-radical damage that leads to hereditary genetic defects, cancer, and acceleration of the aging process. But all is not lost!! There is a valuable natural nutrient tool to use in the protection of your self and your family. It is called HTN's Ellagic Acid and it is contained in the fruit of red raspberries.

But before we can explain to you how these nutrients are able to prevent cancer we must first know what cancer is. What follows is a discussion of the mechanisms of a disease process and how nutritional factors can protect us.

HTN'S ELLAGIC ACID. By Dr. Kurt Grange, Ph.D. Nutritional Biophysiologist

Cancer is the most feared of all diseases.

People immediately associate cancer with dying. Unlike other killer diseases, cancer usually causes a slow death involving pain, suffering, mental anguish, and a feeling of hopelessness. In addition, the mental and physical stress it puts on loved ones and caretakers is beyond calculation.

What is cancer?

You have 76 trillion cells in your body that must constantly undergo reproduction if the body is to remain alive and functioning correctly. Some of these cells reproduce every few days while others reproduce after a much longer period. As each old cell reaches the end of its life cycle, it reproduces and is replaced by a fresh young cell. This natural process is called apoptosis. The normal death rate of cells is controlled by a "biological clock" type of gene called the P53 gene.

We know that most cancers are initiated by the action of free radicals. Free radicals are unstable atoms or molecules with at least one unpaired electron. These unpaired electrons want and need a partner. Consequently, the unstable free radicals, which have the ability to attract electrons from other atoms or molecules, go about swiping electrons from other stable atoms or molecules. This taking of a electron from another atom means that the free radical is now balanced and is no longer a free radical. But the atom or molecule from which the electron was taken is now damaged, and it becomes a free radical. This sets off a domino type chain reaction of damage within the body. Similar to little hand grenades exploding within the cell structure. In their reckless search for electrons, free radicals do a lot of structural damage to healthy cells. Cumulative free radical damage causes the plasma membrane of the cell to break down. When this happens, transportation of nutrients, oxygen, and water into the cell and removal of waste products and toxins out of the cell become compromised. This causes the cell to either starve to death, die in a sea of accumulated toxic waste, or, if the DNA of the cell is also affected, it can cause the cell to reproduce daughter cells incorrectly, thereby causing cell mutation.

The mutated cell is now genetically incorrect and, therefore, does not behave as a normal cell. The P53 gene of the cell is affected and the natural biological clock is stopped, often eliminating apoptosis (natural cell death). Without apoptosis the mutated cancer cell doesn't die. In order to sustain its growth a cancer cell steals nutrients from surrounding cells and begins to rapidly reproduce damaged, mutated cells in geometric progression (2, 4, 8, 16, etc.). Over a period of time the cancer cell develops into a cancerous mass or a tumor. Cancerous cells from the mass or tumor can be transported to other tissues or organs where they imbed and begin to grow and reproduce (metastasize).

In recent years the ability of the medical community to diagnose and treat cancer has greatly improved. Unfortunately, however, the vast majority of cancers still lack effective treatments. The choices for conventional treatment involve some form of surgery, radiation, and/or chemotherapy. These procedures are invasive, treat only the symptoms, and often cause side effects more severe than the disease. Dr. Alan Levine of the University of California Medical School observes, "Most cancer patients in this country die of chemotherapy." He also states that "Chemotherapy does not eliminate breast, colon, or lung cancers. This fact has been documented for over a decade."

Conventional methods treat cancer as a localized disease to be treated in a localized manner by cutting out the tumor, irradiating it, or flooding the body with toxic ( and often carcinogenic) drugs in order to destroy the tumor. On the other hand, natural healing methods consider cancer to be a systemic disease. Emphasis is placed on rebuilding the body's natural immunity and strengthening its natural ability to destroy cancer cells. The key is to Alkalize, Cleanse, Nourish, and Balance the Body, allowing it to heal itself naturally.

Data on cancer (which has been corroborated by the National Academy of Sciences, the U.S. Department of Health and Human Services, the National Cancer Institute, and the American Cancer Society) found that 80-90 percent of all cancers are produced as a result of life-style factors, (smoking, alcohol, lack of exercise), exposure to chemicals, environmental factors, and dietary nutritional practices.

We are surrounded by natural and technologically produced toxins. These environmental poisons are present in the air we breathe, the foods we eat and the water we drink. In today's industrial world, we cannot escape them. We are exposed to more toxins in 15 minutes than our great-grandparents were exposed to during their entire lives. The majority of these toxins are considered to be cancer-causing carcinogens, and , as unbelievable as it sounds, the most toxic environment to which we are exposed daily is the environment in our own homes.

Each of us had contributed the the demise of our own health. In our headlong rush to make our lives easier, safer, faster, more fun, and more convenient, we have changed our lifestyles. And, both accidentally and on purpose, we have also changed our environment. We have created the toxic environment necessary for a variety of old and new disease microbes and degenerative disease conditions, such as cancer, to proliferate and devastate our society.

Since lifestyles, environmental factors, and nutrition are the most common risk factors for developing cancer, it stands to reason that many of these cancers can be destroyed, substantially reduced, or their development eliminated by reducing or eliminating the risk factors. There are some risk factors like air and water which are difficult to control. However, you have almost total control over some of the other known risk factors such as smoking, alcohol, intake of chemicals and drugs, and diet and nutrition.

Diet and nutrition appear to be factors in 60 percent of women's cancers, 40 percent of men's cancers, and about 75 percent of cardiovascular diseases. Space doesn't allow for a discourse on diets and what foods to eat to reduce possible cancer development, except to say, reduce your intake of fat, red meat, smoked meats or those preserved by nitrates, and eliminate from your diet white sugars, white flour products, and especially all soft drinks. They are up to 500 times more acidic than your blood, causing a cascade of health problems.

Unfortunately, most doctors don't counsel cancer patients or those that are at high risk for cancer about nutrition. However, research shows that ingesting the correct foods and supplements may prevent cancer, boost the immune system and energy levels, and give the body a fighting chance to prevent cancer or heal itself. A healthy diet strengthens the immune system, slows tumor growth, protects against further metastasis and reduces the overwhelming negative side effects of radiation and chemotherapy.

Studies repeatedly show that there is a substantial reduction in cancer risk in those who eat or juice the necessary amounts of fresh fruits and vegetables. Only nine percent of Americans eat the recommended five daily servings. Research has found that it is the antioxidants in fruit and vegetables that confer additional protection against free radically induced cancer. Low blood levels of antioxidants are associated with an increase in death rated from many types of cancer.

One of the most promising areas in cancer prevention involving nutrition is in the area of chemoprevention. Chemoprevention is the concept that natural substances found in whole fresh foods could provide powerful weapons against cancer, and against other chronic ailments as well. Chemoprevention is NOT chemotherapy. Instead of toxic poisons, chemoprevention employs nutraceuticals to develop optimal health and to counteract cancer and other chronic and degenerative diseases.

A nutraceutical is a food substance or part of a food that provides medical or health benefits, including the prevention of, and / or treatment of disease. They are naturally occurring compounds found in plants, algae, microbials, and other biological sources which support specific bodily health functions. One of the most powerful nutraceutical chemopreventatives for cancer is an extract from red raspberries seeds and concentrated fruit, called Ellagic Acid.

Ellagic Acid is a nutraceutical. It contains a naturally occurring phenolic compound that has very strong anti-oxidant properties. It is also a potent anti-carcinogen. Ellagic Acid has the ability to inhibit mutations within a cell's DNA. It is also considered to be a cancer inhibitor which has the ability to cause apoptosis or normal cell death in cancer cells. In addition, research has found that it has antibacterial and anti-viral properties.

Dr. Daniel Nixon of the Hollings Cancer Institute at the Medical University of South Carolina, has been working with Ellagic Acid from the red raspberry seed in his cancer studies. Dr. Nixon found that ingesting 40mg of Ellagic Acid, which is the amount of Ellagic Acid contained in 1 cup of red raspberries (and 5 capsules of HTN's Ellagic Acid, Advanced Program), can cause cancer cells to undergo apoptosis (natural cell death). This is important because when cancer cells undergo apoptosis it effectively stops their geometric reproductive progression. The cancer cells die a normal death and are not reproduced. In other words, it reinstates the action of the P53 gene.

Dr. Nixon also has shown that human cervical cells which are infected with the human papilloma virus (which is considered to be the main cause of cervical cancer) are also killed. Other investigations and researchers, both in the United States and in Europe, found that daily consumption of Ellagic Acid from red raspberries had positive responses in:

perlodontal disease protection of the liver from toxic injury faster wound healing radiation induced chromosomal damage slowing the spread of the HIV virus in the human body slowing the degenerative process of aging prevention of neural tube birth defects neurodegenerative diseases diabetic retinopathy What Is Ellagic Acid? HTN's Ellagic Acid is a super antioxidant and a potent anticarcinogen which protects the cells against free radical damage. It is also a very powerful anti-viral and anti-bacterial agent. Ellagic Acid has the ability to inhibit mutations within a cell's DNA. It is also considered to be a cancer inhibitor which has the ability to cause apoptosis or normal death in many different types of cancer cells.

Adding HTN's Ellagic Acid and Alka-Line Coral Calcium or Coral Calcium Gold to the following cancer prevention guidelines is an excellent way to reduce the chance of developing cancer:

Maintain a desirable body weight Eat a varied diet Include a variety of both vegetables and fruits in the daily diet Eat more high-fiber foods, such as whole grain cereals, legumes, vegetables, and fruits Cut down on total fat intake Limit consumption of alcoholic beverages, if you drink at all Limit consumption of salt-cured, smoked and nitrate-preserved foods HTN's Alka-Line Coral Calcium

Dr. Kurt Grange, Ph.D. recognizes that alkalinity is the key to optimum health and that HTN's Alka-Line Coral Calcium dramatically increases the beneficial effects of HTN's Ellagic Acid.

Keys to Regaining and/or Maintaining Your Health Arthur C. Guyton, M.D., Probably the most recognized author on human physiology states in his "Textbook of Medical Physiology" (used to educate medical students): "The first steps in maintaining health is to alkalize the body (pH or acid/alkaline balance). This is one of the most important aspects of homeostasis. Changes in pH alter virtually all body functions." DEFINITION: pH is how alkaline a substance is, 0 is Acid, 7 is Neutral and 14 is Alkaline. BLOOD pH: 7.4 is Normal Health and 7.2 is Death.

"The cells of a healthy body are alkaline while the cells of a diseased body are below a pH of 7.0. The more acidic the cell, the sicker we become. If the body can not alkalize the cells they will become acidic and thus, disease sets it. Our bodies do not manufacture alkalinity, we must supply the alkalinity from an outside source to keep us from becoming acidic and dying." Quoted by: Arthur C. Guyton, M.D.

The Answer is: HTN's Alka-Line Coral Calcium

Optimum alkalinity at the cellular level equates to optimum health It was also learned that when adding 1 gram of Coral Calcium to drinking water (distilled is best) it raised the waters pH to an alkaline 11.5 - 11.73. The 1 gram of Coral Calcium immediately increases the alkaline level by 100,000 times and a the same time adds 100 million free radical fighting electrons. HTN's Alka-Line Coral Calcium in now believed to be the most powerful antioxidant ever discovered. Scientists have long known that the maintenance of body fluids (saliva) at an alkaline pH (7.1 to 7.5) is critical to cellular health.

Ionic form of calcium, the "King of Minerals," immediately bioavailable The calcium and minerals in Alka-Line Coral Calcium (identical to our skeleton structure) become ionic in the water, allowing the calcium, magnesium and trace minerals from the ocean to be readily bioavailable to the cells. Additionally, HTN's Alka-Line Coral Calcium products lower the surface tension of the distilled water, allowing it to penetrate and hydrate to cells easily, carrying in nutrients and removing the toxins and waste residue.

In summary: Healthy cells have a normal life cycle. This process is called apoptosis (normal cell death). The body replaces these dying cells with healthy ones; conversely, cancer cells do not die. They rapidly multiply by cell division (mitosis), making 2 cancer cells, then 4, 8, 16, 32 and so on. In lab and recent clinical studies, Ellagic Acid caused the cancer cells to go through a nontoxic, normal apoptosis process without damaging the healthy cells. Chemotherapy, radiation and most conventional treatments are known to cause the death of cancer cells, but they also cause the death of healthy cells indiscriminately. In most cases destroying the immune system during the treatment process.

SUGGESTED USE: As a dietary supplement take 5 capsules daily. Drink plenty of good water (distilled water treated with Alka-Line!" Coral Calcium is recommended).

Ingredients contained in 800 mg capsules - Meeker Raspberry Seed Flour with Raspberry Fruit Extract. Five 800 mg capsules taken daily deliver 40 mg of pure Ellagitannins which the body converts to Ellagic Acid when consumed. Equal to approximately one cup of fresh raspberries.

KEEP OUT OF CHILDREN'S REACH KEEP LID TIGHTLY CLOSED AND STORE IN A COOL, DRY PLACE Supplement Facts: Serving Size: 5 Capsules (800 mg each) Servings Per Bottle: 30 . Amount Per Serving % Daily* Value Raspberry Seed Flour Raspberry Fruit Extract 4000mg Percent Daily Values are based on a 2000 calorie Diet. + Daily value not established

Other ingredients: Magnesium Sterate, Silica and Guar To order call 1 800 765 0140 use pin #78027 The Raleigh Herb Shop Highly recomend ALKA-LINE CORAL CALCIUM GOLD AND THE BLUE BOTLE - TO BE USED WITH THE ELLAGIC ACID .

Want a career with natural health?

The products and statements mentioned on this site have not been evaluated by the FDA. All information on this site is for educational purposes only .

The Raleigh Herb Shop Raleigh N C 27616

919 875 1005

email john@johnhouser.net

--------------------------- More info on Ellagic Acid

ellagic acid (EA) and quercetin against N-nitrosodiethylamine-induced lung tumorigenesis in mice. Ellagic acid was able to significantly reduce tumour incidence to 20% from the control value of 72.2%. Similarly, tumour burden was also decreased, although not significantly, from 3.15 to 2.5. Quercetin (QR) caused the tumour incidence to decrease from 76.4% to 44.4% when fed until the third dose of carcinogen. Both of the polyphenols suppressed the tumour incidence mainly by acting at the initiation phase of the carcinogenesis, since continuing the feeding of polyphenols until the termination of the experiment did not cause any apparent change in tumour incidence or tumour burden. Besides this, ellagic acid was found to be a better chemopreventor than quercetin. In order to search for their mechanism of action, the effect of feeding of these compounds on reduced glutathione (GSH), an important endogenous antioxidant, and on lipid peroxidation was investigated. Both ellagic acid and QR caused a significant increase in GSH and decrease in NADPH- and ascorbate-dependent lipid peroxidation. Ellagic acid was found to be more effective in decreasing the lipid peroxidation and increasing the GSH. This may be one of the reasons for its observed better anticarcinogenic property as compared to quercetin. MESH TERMS: Animal Anticarcinogenic Agents/*Therapeutic Use Chemoprevention Diethylnitrosamine/*Antagonists and Inhib Ellagic Acid/*Therapeutic Use Glutathione/Metabolism Lipid Peroxidation/Drug Effects Lung Neoplasms/*Prevention and Control Male Mice Microsomes/Drug Effects/Metabolism Oxidation-Reduction Quercetin/*Therapeutic Use LANGUAGE: ENG PUBLICATION TYPE: JOURNAL ARTICLE TITLE ABBREVIATION: Food Chem Toxicol YEAR: 1999 AUTHOR: Khanduja KL, Gandhi RK, Pathania V, Syal N TITLE: Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. SOURCE: Food Chem Toxicol; 37(4):313-8 1999 UI: 99345316 ABSTRACT: The polyphenolic antioxidants, consumed as an integral part of vegetables, fruits and beverages, are suggested as possessing anticarcinogenic properties. In the present study we have looked into the anticarcinogenic potential of plant polyphenols ellagic acid (EA) and quercetin against N-nitrosodiethylamine-induced lung tumorigenesis in mice. Ellagic acid was able to significantly reduce tumour incidence to 20% from the control value of 72.2%. Similarly, tumour burden was also decreased, although not significantly, from 3.15 to 2.5. Quercetin (QR) caused the tumour incidence to decrease from 76.4% to 44.4% when fed until the third dose of carcinogen. Both of the polyphenols suppressed the tumour incidence mainly by acting at the initiation phase of the carcinogenesis, since continuing the feeding of polyphenols until the termination of the experiment did not cause any apparent change in tumour incidence or tumour burden. Besides this, ellagic acid was found to be a better chemopreventor than quercetin. In order to search for their mechanism of action, the effect of feeding of these compounds on reduced glutathione (GSH), an important endogenous antioxidant, and on lipid peroxidation was investigated. Both ellagic acid and QR caused a significant increase in GSH and decrease in NADPH- and ascorbate-dependent lipid peroxidation. Ellagic acid was found to be more effective in decreasing the lipid peroxidation and increasing the GSH. This may be one of the reasons for its observed better anticarcinogenic property as compared to quercetin. MESH TERMS: Animal Anticarcinogenic Agents/*Therapeutic Use Chemoprevention Diethylnitrosamine/*Antagonists and Inhib Ellagic Acid/*Therapeutic Use Glutathione/Metabolism Lipid Peroxidation/Drug Effects Lung Neoplasms/*Prevention and Control Male Mice Microsomes/Drug Effects/Metabolism Oxidation-Reduction Quercetin/*Therapeutic Use LANGUAGE: ENG PUBLICATION TYPE: JOURNAL ARTICLE TITLE ABBREVIATION: Food Chem Toxicol YEAR: 1999 AUTHOR: Khanduja KL, Gandhi RK, Pathania V, Syal N TITLE: Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. SOURCE: Food Chem Toxicol; 37(4):313-8 1999 UI: 99345316 ABSTRACT: The polyphenolic antioxidants, consumed as an integral part of vegetables, fruits and beverages, are suggested as possessing anticarcinogenic properties. In the present study we have looked into the anticarcinogenic potential of plant polyphenols ellagic acid (EA) and quercetin against N-nitrosodiethylamine-induced lung tumorigenesis in mice. Ellagic acid was able to significantly reduce tumour incidence to 20% from the control value of 72.2%. Similarly, tumour burden was also decreased, although not significantly, from 3.15 to 2.5. Quercetin (QR) caused the tumour incidence to decrease from 76.4% to 44.4% when fed until the third dose of carcinogen. Both of the polyphenols suppressed the tumour incidence mainly by acting at the initiation phase of the carcinogenesis, since continuing the feeding of polyphenols until the termination of the experiment did not cause any apparent change in tumour incidence or tumour burden. Besides this, ellagic acid was found to be a better chemopreventor than quercetin. In order to search for their mechanism of action, the effect of feeding of these compounds on reduced glutathione (GSH), an important endogenous antioxidant, and on lipid peroxidation was investigated. Both ellagic acid and QR caused a significant increase in GSH and decrease in NADPH- and ascorbate-dependent lipid peroxidation. Ellagic acid was found to be more effective in decreasing the lipid peroxidation and increasing the GSH. This may be one of the reasons for its observed better anticarcinogenic property as compared to quercetin. MESH TERMS: Animal Anticarcinogenic Agents/*Therapeutic Use Chemoprevention Diethylnitrosamine/*Antagonists and Inhib Ellagic Acid/*Therapeutic Use Glutathione/Metabolism Lipid Peroxidation/Drug Effects Lung Neoplasms/*Prevention and Control Male Mice Microsomes/Drug Effects/Metabolism Oxidation-Reduction Quercetin/*Therapeutic Use LANGUAGE: ENG PUBLICATION TYPE: JOURNAL ARTICLE TITLE ABBREVIATION: Food Chem Toxicol YEAR: 1999 AUTHOR: Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW TITLE: p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. SOURCE: Cancer Lett; 136(2):215-21 1999 UI: 99281882 ABSTRACT: Ellagic acid is a phenolic compound present in fruits and nuts including raspberries, strawberries and walnuts. It is known to inhibit certain carcinogen-induced cancers and may have other chemopreventive properties. The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells. We found that ellagic acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited overall cell growth and induced apoptosis in CaSki cells after 72 h of treatment. Activation of the cdk inhibitory protein p21 by ellagic acid suggests a role for ellagic acid in cell cycle regulation of cancer cells. MESH TERMS: Apoptosis* Blotting, Western Cell Division/Drug Effects Cyclins/*Biosynthesis Dose-Response Relationship, Drug DNA/Biosynthesis DNA Fragmentation Ellagic Acid/*Pharmacology Enzyme Inhibitors/*Metabolism Flow Cytometry G1 Phase/*Drug Effects Human Neoplasms/*Metabolism Protein p53/*Biosynthesis Time Factors Tumor Cells, Cultured LANGUAGE: ENG PUBLICATION TYPE: JOURNAL ARTICLE TITLE ABBREVIATION: Cancer Lett YEAR: 1999 TITLE: [The protective action of ellagic acid in experimental myocarditis] AUTHOR: Iakovleva LV, Ivakhnenko AK, Buniatian ND SOURCE: Eksp Klin Farmakol; 61(3):32-4 1998 UI: 98354527 ABSTRACT: The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis. LANGUAGE: RUS PUBLICATION TYPE: JOURNAL ARTICLE TITLE ABBREVIATION: Eksp Klin Farmakol YEAR: 1998 ADDRESS: Central Research Laboratory, Ukranian Pharmaceutical Academy, Kharkov, Ukraine. AUTHOR: Chen Z, Gundimeda U, Gopalakrishna R TITLE: Ellagic acid induces oxidative inactivation of protein kinase C by modifying both catalytic and regulatory domains (Meeting abstract). SOURCE: Proc Annu Meet Am Assoc Cancer Res; 38:A1395 1997 UI: 98638395 ABSTRACT: Ellagic acid is a polyphenol found in fruits and vegetables, and has been shown to have cancer chemopreventive activity. The mechanism of its antitumor promoting activity is not known. Since protein kinase C (PKC) serves as a receptor for tumor promoters as well as can be oxidatively modified by phenolic compounds, we have determined whether ellagic acid can directly regulate this enzyme. When PKC was preincubated with ellagic acid and then assayed with a low (5 uM) or high (100 uM) concentration of ATP, the enzyme was inhibited with an IC50 of 1 and 4 uM, respectively. Detailed studies revealed that this was due to an irreversible inactivation of the enzyme caused by a redox modification. Ellagic acid-iron complex can inactivate PKC without the need for other metals. Both catalytic and regulatory domains of PKC were modified by ellagic as determined by the loss of kinase activity and phorbol ester binding. But the catalytic domain was 3-fold more sensitive. The thiol agents and vitamin C inhibited this inactivation. In JB6 cells, ellagic acid at low (less than 1 to 5 uM) concentrations induced a modification of PKC which was reversed by an endogenous reduction mechanism, while at higher (5 to 25 uM) concentrations, it induced an irreversible inactivation. Taken together these results suggest that the antitumor promoting action of ellagic acid may be mediated in part by inducing a redox modification of PKC. LANGUAGE: ENG PUBLICATION TYPE: MEETING ABSTRACTS TITLE ABBREVIATION: Proc Annu Meet Am Assoc Cancer Res YEAR: 1997 Ellagic Acid is a phenolic compound that has become a known as a potent anti-carcinogenic/anti-mutagenic compound. It also has anti-bacterial and anti-viral properties. Ellagic acid itself is not thought to be naturally present in plants. Instead, polymers of gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose centers to form the class of compounds known as ellagitannins. When two gallic acid groups become linked side-by-side within a tannin molecule and HHDP group is formed.

Ellagic acid is the result when the HHDP group is cleaved from the tannin molecule and spontaneously rearranges. It is the ellagitannins that are present in red raspberries. Some articles in which ellagitannins are quantified refer to ellagic acid because quantitation of ellagitannins is done by breaking them down into ellagic acid subunits and quantifying the subunits.

The Meeker red raspberry is the best source of ellagic acid followed by Chilliwack and Willamette. The Meeker variety is specific to the Pacific Northwest---grown primarily for commercial use in Washington State. The Chilliwack and Willamette varieties contain lesser variations of ellagic acid. Both of these varieties are grown in the Pacific Northwest and may be found in lesser volumes outside the United States

As an Herb Specialist I have seen more people get good results with HTN products , recently had a client who had cancer , used the HTN product Ellagic Acid for 6 months , she then had an MRI , and the Doctors told her they could find no cancer in her body .

Her name is Mary Copeland at age 74 she glad to be cancer free . She was in Chemo for two long years , and decided to give Herbs and natural health a chance . It Worked ! Please try the natural approach first , change your diet , cut out all carbonated beverages , sodas and colas , do not drink white milk ,avoid white flour, avoid all artificial sweetners and white sugar .

In March of 2001 I found a lump on my right breast. After going to the doctors and having a biopsy, in which the lump was removed and tested, it was found to be infiltrating ductal cancer. The lump was 2.8 cm in diameter, with a grade III rating for lymphatic and vascular invasion. It was recommended that I go thru at least 6 weeks of radiation and then chemo. The oncologists told me in front of my 3 and 9-year-old children that I would die within two years without these treatments. After lots of prayer and knowing what these treatments do to the body, and that they, in fact, can cause cancer, I decided to go another route. My husband Michael gave me tremendous support, researching the internet and every resource he could find for alternative cancer treatments. I took many herbs, vitamins, and immune support products that were excellent along with drastically changing my diet. Then I found HTN, and after researching their products, I decided to use the Health Pak Program along with the Ellagic Acid. I used this program for 3 months, then graduated down to a smaller package. I still continue to use their products for what I see will be a long healthy life. I have not had a sick day since I found the lump. On January 2nd, I received results from a blood that were normal! NO CANCER PRESENT! PRAISE GOD! I will continue to use HTN products to alkalize, cleanse, nourish, and balance my body.

Raleigh Herb Shop
Owner-John Houser, Herb Specialist
919-875-1005

6320 - 132 Capital Blvd.
Raleigh, NC 27616